White Matter Lesions and Cerebral Perfusion Imaging in Late-onset Major Depression
نویسندگان
چکیده
R. B. Dalby, J. Ahdidan, M. Chakravarty, L. Sørensen, R. Rosenberg, L. Østergaard, and P. Videbech Centre for Psychiatric Research, Aarhus University Hospital, Risskov, Denmark, Center of Functionally Integrative Neuroscience, Aarhus University Hospital, Aarhus, Denmark, PET Center, Aarhus University Hospital, Aarhus, Denmark, Department of Neuroradiology, Aarhus University Hospital, Aarhus, Denmark
منابع مشابه
Cerebral white matter lesions and depressive symptoms in elderly adults.
BACKGROUND There is evidence for a vascular cause of late-life depression. Cerebral white matter lesions are thought to represent vascular abnormalities. White matter lesions have been related to affective disorders and a history of late-onset depression in psychiatric patients. Their relation with mood disturbances in the general population is not known. We investigated the relation between wh...
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OBJECTIVES Perfusion SPECT and MRI were used to test the hypothesis that late onset depression is associated with brain abnormalities. METHODS Forty depressed patients (DSM-III-R major depressive episode, not demented at two year follow up) were recruited who were either drug free, or on a stable dose of antidepressants for at least three weeks, as well as 22 demented patients (DSM-IIIR and N...
متن کاملLocalization of white-matter lesions and effect of vascular risk factors in late-onset major depression.
BACKGROUND Several studies suggest that patients with late-onset major depression (MD) have an increased load of cerebral white-matter lesions (WMLs) compared with age-matched controls. Vascular risk factors such as hypertension and smoking may confound such findings. Our aim was to investigate the association between the localization and load of WMLs in late-onset MD with respect to vascular r...
متن کاملDepression severity is correlated to the integrity of white matter fiber tracts in late-onset major depression.
Cerebral white matter lesions (WMLs) are believed to play an important role in a subset of major depression (MD). We aimed to describe the impact of WMLs on white matter pathways in MD using diffusion tensor imaging (DTI) and magnetization transfer imaging. As a novel approach, we used DTI tractography to assess pathways intersected by WMLs. We examined 22 patients with late-onset MD and 22 age...
متن کاملCorrelations between Stroop task performance and white matter lesion measures in late-onset major depression.
Cerebral white matter lesions (WMLs) are believed to play an important role in a subset of patients with late-onset depression by affecting the white matter connectivity in circuitries essential for mood and cognition. In this study we used diffusion tensor imaging-based (DTI-based) tractography to assess white matter fiber tracts affected by deep WMLs (DWMLs) in patients with late-onset major ...
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